Cas9, Transcription Activator-Like Effector Nucleases (TALENs), and Zinc-Finger nucleases (ZFNs) have demonstrated great utility, primarily for genetic knock-out applications, none have been adopted ...

AI protein function prediction uses machine learning models trained on sequence and structural data to infer protein roles at ...

CRISPR gene drives bias inheritance in pests, advancing population-level control while raising questions about resistance and ...

A proposed function of TADs is to contribute to gene regulation by promoting chromatin interactions within a TAD and by suppressing interactions between TADs. Here, we directly probe the ...

Nature Chemical Biology is an international monthly journal that provides a high-visibility forum for the publication of top-tier original research and commentary for the chemical biology community.

A Mini Review summarizing the current understanding of epithelial-mesenchymal transition (EMT) and 3D genome organization, focusing on the role of chromatin conformation and accessibility changes ...

Respiratory supercomplex formation relieves molecular strain of mitochondrial membranes and reshapes global protein motions, linking membrane reorganization to respiratory function.